research areas & PUBLICATIONS

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Research Area-I: Material Science: In-vitro Bio-medical applications of polymers as novel pharmacologically active wound dressing material and anticancer drug

Background: Both phyto and nano fabricated polymers can be engineered to be biocompatible, meaning they are well-tolerated by living organisms. This is crucial for biomedical applications to avoid adverse reactions or immune responses. Nano fabricated polymers can serve as scaffolds for tissue engineering, providing a framework for cell growth and tissue regeneration. Their nanostructure can mimic the natural extracellular matrix, promoting cell attachment, proliferation, and differentiation. To ensure public health comfort and safety, developing bio functionalized wound dressing films using natural extract and optimizing their efficiency are gaining great interest in the field of biomaterials rather than synthetic drug-loaded film and also fabricated polymers can be used as anticancer molecule in resistant cell lines.

Publications

1. Title: Bio functionalization of chitosan/gelatin composite films reinforced Phyllanthus niruri extract for wound healing application. 

Published: Journal: Surfaces and Interfaces; Publisher: Elsevier, IF: 6.2

2. Title: Novel jointured green synthesis of chitosan‑silver nanocomposite: An approach towards reduction of nitroarenes, anti-proliferative, wound healing and antioxidant applications

Published: Journal: International Journal of Biological macro-molecules; Publisher:, Elsevier, IF: 8.2.

3. Title: Basella alba stem extract integrated poly (vinyl alcohol)/chitosan composite films: A promising bio-material for wound healing

Published: Journal: International Journal of Biological macro-molecules; Publisher:, Elsevier, IF: 8.2.

Book Chapters:

1. Chapter Title:  Process Modeling in Biocomposites; Book Name: Handbook of Bioplastics and Biocomposites Engineering Applications; Publisher: Wiley.

2. Chapter Title:  Artificial Intelligence in Material Genomics; Book Name: Application of Artificial Intelligence in New Materials Discovery; Publisher: Material Research Forum.

3. Chapter Title:  Applications of Polysaccharides in Cancer Treatment; Book Name: Polysaccharides: Properties and Applications; Publisher: Wiley.

4. Chapter Title:  Applications of polysaccharides in nutrition and medicine; Book Name: Polysaccharides: Properties and Applications; Publisher: Wiley.

5. Chapter Title:  Polysaccharides as novel materials for tissue engineering applications; Book Name: Polysaccharides: Properties and Applications; Publisher: Wiley. 

6. Chapter Title: Greener composites from plant fibers: Preparation, structure, and properties; Book Name: Polysaccharides: Properties and Applications; Publisher: Wiley. 

Research Area-II: Nanotechnology: In-vitroBio-medical applications of Nanoparticles 

Background: Nanoparticles hold significant promise in the field of cancer treatment due to their unique properties. Nanoparticles can be engineered to specifically target cancer cells while sparing healthy tissues. This targeted delivery reduces systemic toxicity and enhances the efficacy of chemotherapy drugs. Nanoparticles can bypass biological barriers such as the blood-brain barrier (BBB) or the extracellular matrix, facilitating the delivery of drugs to previously inaccessible sites, including metastatic tumors in the brain. Overall, nanoparticles offer a versatile platform for improving cancer diagnosis, treatment, and monitoring, with the potential to revolutionize oncology by enabling more effective and personalized therapeutic strategies.

Publications

1. Title: Nanocrystal engineering: Unraveling bioactivities and augmented photocatalytic degradation of ZnO and Cr-doped ZnO via green and chemical synthesis routes. 

Published: Journal: Journal of Molecular Structure, Elsevier, 2024 (IF-3.8).

2. Title: Dexterous green synthesis of Cu2O nanoparticles: An amenable catalyst for aqueous click reaction, antiproliferative, and wound healing applications.

Published: Journal:  Applied Organometallic Chemistry, Wiley, 2024 (IF-3.9).

3. Title: Succinct and Expeditious Synthesis of Cu2O Nanoparticles by Using Liquid Jaggery: Anticancer and Wound Healing Activity Analyses.

Published: Journal: Chemistry Select, Wiley, (IF-2.1).

4. Title: A Pilot Study: Changes Of Mdamb-231 Cancer Cell Line Response To Synthesized Oleic Acid–Coated Mgfe2o4 Nano Ferrite Compound And Its Cytotoxic Effects On L929 Cell Line

Published: Journal: Chemical Physics Impact. Elsevier (IF-2.2).

5. Title: Multifunctional role of Engineered Tin Oxide Nanoparticles with the variation of calcination temperatures.

Published: Journal: Materials Today Communications, Elsevier (Impact Factor-3.66).

6. Title: Green synthesis, characterization and biomedical applications of Centella asiatica‑derived carbon dots.

Published: Journal: Carbon Letters, Publisher: Springer Nature (IF-3.117).

7. Title: Synthesis and Characterization of Silver Nanoparticles from Rhizophora apiculata and Studies on Their Wound Healing, Antioxidant, Anti-Inflammatory, and Cytotoxic Activity.

Published: Journal: Molecules, MDPI (Impact Factor-5.110).

8. Title: Green Synthesis and Characterization of Iron Nanoparticles Synthesized from Aqueous Leaf Extract of Vitex leucoxylon and Its Biomedical Applications.

Published: Journal: Nanomaterials, MDPI (Impact Factor-5.810).

9. Title: Green synthesis of Manganese nanoparticles from Microalgae Tetradesmus acuminatusisolated from freshwaters of Dharwad and evaluation of their Antioxidant and Anti-inflammatory activity.

Published: Journal: Research Journal of Biotechnology, Scopus (IF- 0.350).

Book Chapters:

1. Chapter Title:  Nanoparticles and Nanomaterials: An Update; Book Name: Biogenic Nanomaterials; Publisher: Apple Academic Press.

2. Chapter Title:  Microbes and agricultural waste: A safe resource for the production of bionanomaterials; Book Name: Agri-Waste and Microbes for Production of Sustainable Nanomaterials; Publisher: Elsevier.

3. Chapter Title:  Nanomaterials from Biomass: An Update; Book Name: Handbook of Nanomaterials and Nanocomposites for Energy and Environmental Applications; Publisher: Springer.

4. Chapter Title:  Nanomaterials for decontamination of organophosphorus compounds in soil; Book Name: Nanomaterials for Soil Remediation; Publisher: Elsevier.

5. Chapter Title:  Nano-bubble technology for remediation of metal-contaminated soil; Book Name: Nanomaterials for Soil Remediation; Publisher: Elsevier.

6. Chapter Title:  Nanosensors for detection and evaluation of organic compounds in soil; Book Name: Nanomaterials for Soil Remediation; Publisher: Elsevier. 

7. Chapter Title: Mesoporous Nanomaterials: Properties and Applications in Environmental Sector; Book Name: Handbook of Nanomaterials and Nanocomposites for Energy and Environmental Applications; Publisher: Springer. 

8. Chapter Title: Nanomaterials from agro wastes: past, present, and the future; Book Name: Handbook of Nanomaterials and Nanocomposites for Energy and Environmental Applications; Publisher: Springer. 

Research Area-III: Medicinal Chemistry: In-vitroBio-medical applications organic synthetic molecules and plant and microbial based potent chemicals 

Background: Organic synthetic compounds are often used as starting points for drug discovery programs. Medicinal chemists design and synthesize novel organic molecules with desired pharmacological properties, such as improved efficacy and reduced side effects. Plant-based phytochemicals are also screened for their potential as drug candidates, as they often possess bioactive properties. Many organic synthetic compounds and phytochemicals have shown promise in cancer treatment. For example, taxanes, derived from the Pacific yew tree, are used in chemotherapy to treat various types of cancer. Additionally, synthetic compounds like imatinib have revolutionized the treatment of certain cancers by targeting specific molecular pathways.

Publications

1. Title: Design, Synthesis and Characterization of novel 1,5- and 2,5-coumarin-4-yl-methyl regioisomers of 5-pyrazol-3-yl-tetrazoles as promising anticancer and antifungal agents.

Published: Journal: Journal of Molecular Structure, Elsevier, 2024 (IF-3.8).

2. Title: GCMS‑based phytochemical profiling and in vitro pharmacological activities of plant Alangium salviifolium (L.f) Wang

Published: Journal: Future Journal of Pharmaceutical Sciences (2024) 10:61. Springer (IF-2.6). 

3. Title: Designing and synthesis of novel fluorescent 2-(acryloxy)-3-(4,5-diaryl)-1H-imidazol-2- yl)quinolines: Solvatochromic, DFT, TD-DFT Studies, COX-1 and COX-2 hibinition and antioxidant properties.

Published: Journal: Journal of Fluorescence , Springer. (IF. 2.7).

4. Title: Manilkara zapota L. extract topical ointment application to skin wounds in rats speeds up the healing process.

Published: Journal: Frontiers in Pharmacology, (IF.5.998).

5. Title: Cytotoxic Activity of Vitex leucoxylon Aqueous Leaf Extract Against A549 and NCIH-460 Lung Cancer Cell Lines.

Published: Journal: Frontiers in Pharmacology, (IF.5.998).

6. Title: A new approach for the synthesis of tri-substituted pyrazole propionic acids derivatives: Anti- inflammatory, antimicrobial and molecular docking studies.

Published: Journal: Journal of Molecular Structure, Elsevier (IF- 3.841).

7. Title: A Preliminary Cytotoxicity Study of Fagonia arabica against Breast (MCF-7), Oral (KB-3-1), and Lung Cancer (A-549) Cell Lines: A Study Supported by Molecular Marker Analysis Using Dual Staining Dyes

Published: Journal: Separations, 2023 (10) 2, (MDPI) (Impact Factor-3.344).

8. Title: Coumarin-4-yl‐1, 2, 3‐triazol‐4-yl-methyl-thiazolidine-2, 4-diones: Synthesis, glucose uptake activity and cytotoxic evaluation

Published: Journal: Bioorganic Chemistry, 2023, Elsevier (Impact Factor-5.307)

9. Title: Click approach for synthesis of 3, 4-dihydro-2(1H) quinolinone, coumarin moored 1,2,3- triazoles as inhibitor of mycobacteria tuberculosis H37RV, their antioxidant, cytotoxicity and in- silico studies

Published: Journal: Journal of Molecular Structure, Elsevier (Impact Factor-3.841).

10. Title: Apoptotic Cell Death via Activation of DNA Degradation, Caspase-3 Activity, and Suppression of Bcl-2 Activity: An Evidence-Based Citrullus colocynthis Cytotoxicity Mechanism toward MCF-7 and A549 Cancer Cell Lines

Published: Journal: Separations, 2022, 9 (12), (MDPI) (Impact Factor-3.344).

11. Title: Tribulus terrestrisCytotoxicity against Breast Cancer MCF-7 and Lung Cancer A549 Cell Lines Is Mediated via Activation of Apoptosis, Caspase-3, DNA Degradation, and Suppressing Bcl-2 Activity

Published: Journal: Separations, 2022, 9 (12), (MDPI) (Impact Factor-3.344).

12. Title: In-Vitro Cytotoxicity and Spectral Analysis-Based Phytochemical Profiling of Methanol Extract of Barleria hochstetteri, and Molecular Mechanisms Underlying Its Apoptosis-Inducing Effect on Breast and Lung Cancer Cell Lines

Published: Journal: Separations, 2022, 9 (12), (MDPI) (Impact Factor-3.344).

13. Title: Phytochemicals from Corchorus olitorius methanolic extract induce apoptotic cell death via activation of caspase-3, anti-Bcl-2 activity, and DNA degradation in breast and lung cancer cell lines

Published: Journal: Journal of King Saud University-Science, Elsevier (Impact Factor-3.829).

14. Title: Novel (quinolin-8-yl-oxy)-pyrazole/thiophene derivatives: Synthesis, characterization and their pharmacological evaluation

Published: Journal: Results in Chemistry, 2022, 4, Elsevier.

15. Title: Design, synthesis, molecular docking and biological activity studies of novel coumarino- azetidinones

Published: Journal: Journal of Molecular Structure, Elsevier (Impact Factor-3.841).

16. Title: Biodegradation of diazo reactive dye (Green HE4BD) by Marasmius sp. BBKAV79

Published: Journal: Chemical Data Collections,  Elsevier.

17. Title: Anticancer activity studies of novel metal complexes of ligands derived from polycyclic aromatic compound via greener route

Published: Journal: Journal of Organometallic Chemistry, Elsevier (Impact Factor-2.345).

18. Title: Synthesis of novel metal (II) complexes tailored from 9-oxo-9H-fluorene-1-carboxylic acid via green protocol: DNA cleavage and anticancer studies

Published: Journal: Inorganica Chimica Acta, Elsevier (Impact Factor-3.118).

19. Title: Scorpionate ligand derived from 1-amino-9H-fluoren-9-ol and its metal (II) complexes as potential anticancer agents

Published: Journal: Chemical Data Collections,  Elsevier.

20. Title: Design, Synthesis and Computational Studies of Novel Carbazole N‐phenylacetamide Hybrids as Potent Antibacterial, Anti‐inflammatory, and Antioxidant Agents,

Published: Journal: Journal of Heterocyclic Chemistry, Wiley (Impact Factor-2.035).

21. Title: Physicochemical properties, antioxidant and anti-inflammatory activities of coumarin- carbonodithioate hybrids

Published: Journal: Asian Pacific Journal of Tropical Biomedicine, Elsevier (Impact Factor-1.514).

22. Title: In vitro antidiabetic activities and GC-MS phytochemical analysis of Ximenia americana extracts

Published: Journal: South African Journal of Botany, Elsevier (Impact Factor-3.111).

23. Title: In-vitro Biomedical Application of Endophytic Aspergillus melleus Isolated from Leaves of Premna serratifolia L. (2024)

Published: Journal: Journal of Pure and Applied Microbiology, Scopus 

Current on Going Research 

Research Area-III: Development of polymer based nanosensor devices and drugs for early diagnosis and treatment of cancer 

Background: Modify the polymer surface with ligands or receptors that can selectively bind to cancer-specific molecules, such as proteins, nucleic acids, or small molecules. This step enhances the sensor's specificity. Integrate sensing elements such as fluorescent dyes, quantum dots, or magnetic nanoparticles into the polymer matrix to enable detection and imaging of cancer biomarkers. Polymer-based nanosensors can detect cancer biomarkers at extremely low concentrations due to their large surface area-to-volume ratio and enhanced signal amplification capabilities. In summary, polymer-based nanosensors hold great promise for revolutionizing cancer diagnosis and treatment by offering enhanced sensitivity, specificity, biocompatibility, and multifunctionality. Their tailored design and non-invasive imaging capabilities make them invaluable tools in the fight against cancer.

Research Area-IV: Development of eco-friendly cost effective polymer based bio-patch for wound healing and tissue engineering applications 

Background: Natural polymer-based membranes offer several advantages for wound dressing and tissue engineering applications, owing to their biocompatibility, biodegradability, and similarity to the extracellular matrix. Natural polymers such as chitosan, collagen, alginate, and hyaluronic acid are inherently biocompatible, minimizing the risk of adverse reactions when in contact with biological tissues. This property promotes cell adhesion, proliferation, and tissue regeneration. Some natural polymers possess inherent antimicrobial properties or can be modified to incorporate antimicrobial agents. This helps prevent infection in wounds, reducing the risk of complications and promoting healing. natural polymer-based membranes offer a range of advantages including biocompatibility, biodegradability, similarity to the ECM, moisture retention, controlled drug delivery, flexibility, ease of processing, antimicrobial properties, and cost-effectiveness, making them highly promising materials for wound dressing and tissue engineering applications.